Iron chelation in treatment of superficial siderosis

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Superficial siderosis.

Case 1 An elderly patient presented with insidious onset of sensorineural hearing loss. The past history was unremarkable except for insidious onset of weakness of left lower limb. Physical examination revealed left hemiparesis with upgoing left plantar. Magnetic resonance imaging (MRI) of brain revealed a large flow void in the interpeduncular cistern suggestive of aneurysm arising from the to...

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Regional siderosis: a new challenge for iron chelation therapy

The traditional role of iron chelation therapy has been to reduce body iron burden via chelation of excess metal from organs and fluids and its excretion via biliary-fecal and/or urinary routes. In their present use for hemosiderosis, chelation regimens might not be suitable for treating disorders of iron maldistribution, as those are characterized by toxic islands of siderosis appearing in a b...

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Superficial cortical siderosis.

Cerebrovascular deposition of amyloid (cerebral amyloid angiopathy CAA) is most commonly recognized as a cause of spontaneous lobar intracerebral hemorrhage. On the basis of the noninvasive new MR imaging we would propose superficial cortical hemosiderosis and subarachnoid hemosiderosis as potentially useful new criteria to facilitate the diagnosis of CAA.

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Vestibular function in superficial siderosis

BACKGROUND Superficial siderosis (SS) is caused by repeated or continuous bleeding into the subarachnoid space that results in iron from hemoglobin (hemosiderin) being deposited on the surface of the brain. Clinically, the condition is characterized by sensorineural deafness, ataxia, and pyramidal signs. However the mechanism of peripheral vestibular disturbance was not revealed. We show the ve...

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Superficial siderosis in cerebral amyloid angiopathy

With great interest, we read the recent review article by Kumar entitled “Neuroimaging in Superficial Siderosis: An In-Depth Look,” published on-line ahead of print in the American Journal of Neuroradiology in September 2009. The author provides a thorough review of neuroimaging in superficial siderosis (SS) of the central nervous system and details important underlying causes of this phenomeno...

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ژورنال

عنوان ژورنال: Iranian Journal of Neurology

سال: 2019

ISSN: 2252-0058,2008-384X

DOI: 10.18502/ijnl.v17i4.596